Prime Medicine Verified
Biotechnology, Gene Therapy, Pharmaceuticals
Senior Scientist, Drug Metabolism & Pharmacokinetics (DMPK)
Cambridge, Massachusetts, United StatesOnsiteFull TimeSenior$145,000–$177,000 /yrPosted 2 months agoVisa sponsorship availableHidden Gem · VC-Backed
Role summary
Prime Medicine is seeking a Senior Scientist, DMPK to join their Nonclinical Development group. This role will focus on supporting gene editing therapies by analyzing and interpreting in vivo DMPK data, contributing to regulatory documents, and collaborating with cross-functional teams and external CROs. The ideal candidate will have a strong foundation in in vivo pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, proficiency in NCA using Phoenix WinNonlin, and experience with bioanalytical assay development. The position requires 6+ years of industry experience and involves providing scientific guidance to CROs and presenting complex data to multidisciplinary audiences.
<div class="content-intro"><p><strong>Company Overview:</strong></p>
<p>Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. </p>
<p>Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit <a href="http://www.primemedicine.com/">www.primemedicine.com</a>.</p></div><h1>Position Overview</h1>
<p>We are seeking a motivated and skilled Senior Scientist to join the Nonclinical Development group, contributing to the DMPK function in support of exploratory and IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, DMPK/Bioanalytical Sciences, this individual will independently analyze and interpret datasets from <em>in vivo </em>studies, contribute to nonclinical regulatory documents, and work cross-functionally with pharmacology, translational biology and external CROs, to ensure high-quality DMPK data packages are delivered to support program timelines. The ideal candidate has a strong foundation in <em>in vivo</em> pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, thrives in a fast-paced and matrixed organization, and possesses the flexibility and positive attitude needed to make meaningful contributions to the Nonclinical Development team.</p>
<h1>Primary Responsibilities</h1>
<ul>
<li>Analyze and interpret PK study data from exploratory and IND-enabling <em>in vivo</em></li>
<li>Perform non-compartmental analysis (NCA) using Phoenix WinNonlin to derive key PK parameters (Cmax, AUC, T½, Vd, CL).</li>
<li>Leverage expertise in DMPK to provide recommendations for <em>in vivo</em> study designs in collaboration with pharmacology and key stakeholders.</li>
<li>Perform bioanalytical assay development (30%) and collaborate with bioanalytical scientists to trouble-shoot challenges during method development to ensure quantitative methods for key analytes (LNP lipid components, mRNA, pegRNA, PD biomarkers) meet regulatory expectations and data quality standards..</li>
<li>Contribute to nonclinical regulatory documents including pharmacokinetics summaries and nonclinical study reports under the guidance of senior stakeholders in Nonclinical Development.</li>
<li>Maintain thorough records in the electronic laboratory notebook (ELN); prepare clear data summaries, presentations, and technical memos for program team and governance meetings.</li>
</ul>
<p> </p>
<h1>Qualifications</h1>
<p><strong>Minimum Qualifications</strong></p>
<ul>
<li>D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biochemistry, or a related discipline.</li>
<li>6+ years of cumulative experience. Industry experience (biotech or pharmaceutical) with direct responsibility for <em>in vivo</em> DMPK study design, execution, and interpretation is required; postdoctoral training in a DMPK or translational pharmacology setting is strongly preferred</li>
<li>Demonstrated experience with <em>in vivo</em> PK studies in preclinical models and proficiency in NCA using Phoenix WinNonlin or equivalent software.</li>
<li>Familiarity with regulatory expectations for nonclinical DMPK assessments and bioanalytical assay development.</li>
<li>Demonstrated ability to coordinate with external CROs, including scientific guidance, protocol development, and data review..</li>
<li>Strong written and verbal communication skills; ability to present complex DMPK data clearly to multidisciplinary audiences.</li>
<li>Highly self-motivated, collaborative, and organized, with the ability to manage multiple priorities independently in a fast-paced matrix environment.</li>
</ul>
<p> </p>
<p><strong>Preferred Qualifications</strong></p>
<ul>
<li>Familiarity with PK/PD modeling concepts; experience with Phoenix WinNonlin modeling modules a plus.</li>
<li>Experience with LNP-based delivery systems and/or RNA therapeutics (mRNA, siRNA, ASO, sgRNA or related modalities).</li>
<li>Experience with exploratory DMPK studies, evaluating new delivery vehicles and evaluation of biodistribution using <em>in vivo</em></li>
<li>Familiarity with bioanalytical platforms supporting DMPK studies, including LC-MS/MS, RT-qPCR/ddPCR, ELISA/MSD.</li>
<li>Ability and excitement to contribute to the development and success of the Nonclinical Development team.</li>
</ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p>The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).</p>
<p>Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.</p>
<p>Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.</p></div><div class="title">U.S. Pay Range</div><div class="pay-range"><span>$145,000</span><span class="divider">—</span><span>$177,000 USD</span></div></div></div><div class="content-conclusion"><p>Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.</p></div>
<p>Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. </p>
<p>Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit <a href="http://www.primemedicine.com/">www.primemedicine.com</a>.</p></div><h1>Position Overview</h1>
<p>We are seeking a motivated and skilled Senior Scientist to join the Nonclinical Development group, contributing to the DMPK function in support of exploratory and IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, DMPK/Bioanalytical Sciences, this individual will independently analyze and interpret datasets from <em>in vivo </em>studies, contribute to nonclinical regulatory documents, and work cross-functionally with pharmacology, translational biology and external CROs, to ensure high-quality DMPK data packages are delivered to support program timelines. The ideal candidate has a strong foundation in <em>in vivo</em> pharmacokinetics for RNA therapeutics and/or LNP-based delivery systems, thrives in a fast-paced and matrixed organization, and possesses the flexibility and positive attitude needed to make meaningful contributions to the Nonclinical Development team.</p>
<h1>Primary Responsibilities</h1>
<ul>
<li>Analyze and interpret PK study data from exploratory and IND-enabling <em>in vivo</em></li>
<li>Perform non-compartmental analysis (NCA) using Phoenix WinNonlin to derive key PK parameters (Cmax, AUC, T½, Vd, CL).</li>
<li>Leverage expertise in DMPK to provide recommendations for <em>in vivo</em> study designs in collaboration with pharmacology and key stakeholders.</li>
<li>Perform bioanalytical assay development (30%) and collaborate with bioanalytical scientists to trouble-shoot challenges during method development to ensure quantitative methods for key analytes (LNP lipid components, mRNA, pegRNA, PD biomarkers) meet regulatory expectations and data quality standards..</li>
<li>Contribute to nonclinical regulatory documents including pharmacokinetics summaries and nonclinical study reports under the guidance of senior stakeholders in Nonclinical Development.</li>
<li>Maintain thorough records in the electronic laboratory notebook (ELN); prepare clear data summaries, presentations, and technical memos for program team and governance meetings.</li>
</ul>
<p> </p>
<h1>Qualifications</h1>
<p><strong>Minimum Qualifications</strong></p>
<ul>
<li>D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biochemistry, or a related discipline.</li>
<li>6+ years of cumulative experience. Industry experience (biotech or pharmaceutical) with direct responsibility for <em>in vivo</em> DMPK study design, execution, and interpretation is required; postdoctoral training in a DMPK or translational pharmacology setting is strongly preferred</li>
<li>Demonstrated experience with <em>in vivo</em> PK studies in preclinical models and proficiency in NCA using Phoenix WinNonlin or equivalent software.</li>
<li>Familiarity with regulatory expectations for nonclinical DMPK assessments and bioanalytical assay development.</li>
<li>Demonstrated ability to coordinate with external CROs, including scientific guidance, protocol development, and data review..</li>
<li>Strong written and verbal communication skills; ability to present complex DMPK data clearly to multidisciplinary audiences.</li>
<li>Highly self-motivated, collaborative, and organized, with the ability to manage multiple priorities independently in a fast-paced matrix environment.</li>
</ul>
<p> </p>
<p><strong>Preferred Qualifications</strong></p>
<ul>
<li>Familiarity with PK/PD modeling concepts; experience with Phoenix WinNonlin modeling modules a plus.</li>
<li>Experience with LNP-based delivery systems and/or RNA therapeutics (mRNA, siRNA, ASO, sgRNA or related modalities).</li>
<li>Experience with exploratory DMPK studies, evaluating new delivery vehicles and evaluation of biodistribution using <em>in vivo</em></li>
<li>Familiarity with bioanalytical platforms supporting DMPK studies, including LC-MS/MS, RT-qPCR/ddPCR, ELISA/MSD.</li>
<li>Ability and excitement to contribute to the development and success of the Nonclinical Development team.</li>
</ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p>The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).</p>
<p>Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.</p>
<p>Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.</p></div><div class="title">U.S. Pay Range</div><div class="pay-range"><span>$145,000</span><span class="divider">—</span><span>$177,000 USD</span></div></div></div><div class="content-conclusion"><p>Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.</p></div>