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Biotechnology, Pharmaceutical, Artificial Intelligence, Drug Discovery

Research Scientist II - In Vivo Science

Vancouver, BCOnsiteFull TimeCA$95,000–CA$112,000 /yrPosted 1 month ago

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Required skills

  • oncology
  • immuno-oncology
  • biologics
  • drug development
  • in vivo
  • pharmacology
  • PK/PD
  • efficacy
  • biomarker
  • target engagement

Nice to have

  • translational studies
  • CROs
  • ex vivo experimental plans
  • analytical methodologies
  • hit identification
  • candidate selection

Role summary

Seeking a lab-based Research Scientist II to join our Vancouver team, focusing on in vivo models to generate biological insights for drug development. Responsibilities include designing, executing, and analyzing in vivo efficacy and pharmacology studies, developing novel animal models, and assessing target engagement and biomarker modulation. The role involves collaborating with cross-functional teams, external CROs, and mentoring junior scientists. Requires a PhD or MSc in a related field with relevant industry experience, particularly in oncology, immuno-oncology, and biologics drug development, along with hands-on experience in in vivo pharmacology and research ethics. This position plays a crucial role in advancing drug candidates from discovery through to clinical trials.

Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients who need them. We pursue truth and scientific rigour and have the courage to work at the edge of the unknown.

We are looking for a lab-based Research Scientist II to join our Vancouver team and become a bridge between our in vivo models and the biological insights that shape our pipeline’s future. Working alongside experienced pharmacologists, you will support the design, execution, and analysis of in vivo studies that reveal how our drug to candidates behave in physiologically relevant settings to inform important go/no-go decisions on our programs. This is hands-on, detail-driven science, and your rigour and curiosity will play a direct role in getting new medicines closer to the patients who need them.

How you might spend your days

  • Working with team members and project teams to define the preclinical in vivo strategy to advance pipeline programs from hit identification through candidate selection
  • Collaborating with the In Vivo Models Team to design, develop, and validate novel animal models to expand internal capabilities and capture complex disease biology
  • Designing, coordinating, and interpreting robust in vivo efficacy and pharmacology studies to generate efficacy data and build high confidence in lead candidate selection
  • Collaborating with in vitro biology, protein engineering, and pharmacokinetics (PK/PD) scientists, as well as external CROs, to execute translational studies to screen and optimize lead molecules and advance programs toward human clinical trials
  • Developing, performing, and supervising sample analysis to assess target engagement, biomarker modulation, and downstream pathway effects
  • Training and mentoring junior scientists in ex vivo experimental plans and analytical methodologies
  • Synthesizing and reporting complex research findings to internal program teams and senior leadership to enable clear, data-driven decisions

    • We’d love to hear from you if

  • You have a PhD in pharmacology, immunology, or a related field with 2-5 years of relevant industry experience, or an MSc with 5-8 years of experience, including hands-on work in oncology, immuno-oncology, and biologics drug development
  • You have hands-on experience designing and interpreting in vivo pharmacology models to assess PK, PD, and efficacy of test articles
  • You have a strong understanding of research ethics specific to animal care
  • You are genuinely curious, with an interest in discussing innovative ideas in a highly collaborative, cross-functional and fast paced environment
  • You communicate scientific and/or technical concepts effectively, with an emphasis on application
  • You have a proven track record of independently identifying project needs and translating them into practical, well-executed solutions
  • You enjoy tackling complex biological questions and building datasets that help predict which therapies will succeed

    • What we offer

    AbCellera’s hiring range for this role is CAD $95,000 - $112,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

    You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find a strong sense of community and connections across AbCellera through our work, clubs, and socials.

    About AbCellera

    Creating medicines is the most important work we can do.

    We are a clinical-stage biotechnology company focused on discovering and developing antibody-based medicines in the areas of endocrinology, women’s health, immunology, and oncology. We have built a platform for advancing antibody drug programs from target to clinic, and we are using it to build our internal pipeline. Today, our pipeline includes two drug candidates in clinical development, two preclinical development candidates (DCs) in Investigational New Drug (IND)-enabling activities, and more than 20 active discovery programs across multiple modalities and indications.

    We believe that when tenacious people share a vision and work together, they can truly have a positive impact. That’s why we hire for character and intelligence, not just for CVs or experience.

    We look for people with drive and energy. People we trust. People who need to know their days are being well spent. That their work really matters. In the end, our success will be measured by the impact of our medicines.

    To apply

    Please submit your application through our website and refer to Job ID 23402 in your cover letter. We receive a large volume of applications and are only able to contact those who are selected for an interview. All communication from our Talent Discovery team will come from an @abcellera.com email address.

    Ready to apply?
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