Senior Systems Analyst, Data Operations

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Amylyx Pharmaceuticals is seeking a highly motivated and hands-on Senior Systems Analyst, Data Operations to support and continuously improve our enterprise data and analytics ecosystem.

This role is responsible for maintaining the day-to-day operation of critical data platforms, integrations, and reporting solutions that support Commercial, Medical, R&D, Quality, Finance, and Corporate functions. The successful candidate will ensure that data pipelines, system integrations, master data processes, and reporting environments operate reliably, accurately, and efficiently.

The individual will serve as the primary operational lead for data platform support, troubleshooting, incident resolution, and vendor coordination while also partnering with business stakeholders to identify enhancement opportunities and deliver new capabilities.

This is a highly hands-on role requiring deep technical expertise across Snowflake, Power BI, Talend/Qlik Data Integration, Python, SQL, APIs, and Master Data Management (MDM).

The role will work closely with managed service providers (MSPs), implementation partners, internal IT teams, and business stakeholders to ensure the delivery of high-quality, scalable data solutions that support Amylyx's growing business needs.

Responsibilities

Data Operations & Platform Support

Monitor and support day-to-day operations of Amylyx's enterprise data platform and analytics ecosystem.

Ensure successful execution of data ingestion, transformation, integration, and reporting processes.

Monitor scheduled jobs, data pipelines, interfaces, workflows, and report refreshes to ensure reliable performance.

Identify, troubleshoot, and resolve production issues impacting data availability, quality, or performance.

Perform root cause analysis and implement corrective and preventive actions.

Coordinate and manage incident resolution activities across internal teams and external support providers.

Establish and maintain operational dashboards, monitoring tools, alerting mechanisms, and service metrics.

Ensure adherence to service-level agreements (SLAs) and operational support processes.

Data Engineering & Technical Support

Perform hands-on development, maintenance, and support of data integration processes and workflows.

Develop and support ELT/ETL processes using:

Snowflake, Talend/Qlik Data Integration, Python, SQL, APIs

Support data ingestion from enterprise systems including:

Veeva, Salesforce, NetSuite, HR systems, Data vendors, Third-party SaaS platforms

Execute code reviews and ensure adherence to development standards.

Optimize database performance, data transformations, and reporting processes.

Support environment migrations, deployments, testing, and release management activities.

Master Data Management (MDM)

Support and maintain enterprise Master Data Management processes and solutions.

Manage customer, product, organization, territory, and reference data maintenance activities.

Monitor data quality metrics and proactively identify data issues.

Investigate and resolve master data discrepancies and integration issues.

Collaborate with business stakeholders to improve data governance and stewardship processes.

Support implementation and maintenance of data quality controls and standards.

Business Analysis & Solution Delivery

Partner with business stakeholders to gather, document, and prioritize business requirements.

Facilitate workshops, requirements sessions, and process reviews.

Translate business requirements into technical designs and implementation plans.

Evaluate requests for enhancements, reports, dashboards, integrations, and automation opportunities.

Coordinate development activities between internal teams and external implementation partners.

Perform functional and technical testing to validate delivered solutions.

Ensure solutions are delivered on time, within scope, and meet quality expectations.

Support user acceptance testing (UAT), training, and adoption activities.

Reporting & Analytics Support

Support and maintain Power BI reporting solutions and semantic models.

Troubleshoot report refresh failures, data discrepancies, and performance issues.

Partner with business users to improve reporting capabilities and KPI delivery.

Develop or enhance dashboards and reports as needed.

Ensure reporting solutions align with business requirements and data standards.

Vendor & MSP Management

Serve as primary operational liaison for managed service providers and external partners.

Manage day-to-day activities of outsourced support and development teams.

Track service performance, issue resolution, backlog management, and deliverables.

Review technical deliverables and ensure compliance with Amylyx standards.

Escalate issues and risks as appropriate.

Drive continuous improvement initiatives with vendors and support partners.

Required Qualifications

Bachelor's degree in Information Systems, Computer Science, Engineering, Business, or related discipline.

5+ years of experience supporting enterprise data platforms, data warehouses, analytics solutions, or data operations environments.

Strong hands-on experience with:

Snowflake, SQL/SnowSQL, Python, Power BI, Talend or Qlik Data Integration

Strong experience supporting production data operations and troubleshooting complex data issues.

Hands-on experience with Master Data Management (MDM), reference data management, and data quality processes.

Experience developing and supporting ETL/ELT pipelines and data integrations.

Experience working with APIs, file-based integrations, and SaaS application integrations.

Strong understanding of:

Data Warehousing, Data Modeling, Data Governance, Data Quality, Integration Architecture

Experience gathering business requirements and converting them into technical solutions.

Experience managing external vendors, consultants, or managed service providers.

Strong problem-solving, analytical, and troubleshooting skills.

Excellent communication skills with both technical and non-technical audiences.

Preferred Qualifications

Experience in biotechnology, pharmaceuticals, healthcare, or regulated industries.

Experience supporting commercial pharmaceutical data environments.

Experience supporting commercial data sources such as:

Specialty Pharmacy, Specialty Distributor, Claims Data, Patient Services, Formulary and Market Access Data

Experience working in Agile delivery environments.

Snowflake, Microsoft, Talend, Qlik, or Power BI certifications.

Work Location and Conditions

At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.

When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Base salary is one component of Amylyx’s total rewards package. In addition to competitive base pay, eligible employees may receive annual performance-based bonuses and equity awards, providing an opportunity to share in the company’s long-term success. Amylyx also offers a comprehensive benefits package designed to support the health, well-being, and financial security of our employees.

Estimated Pay Range$138,000—$155,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.