Scientist III, Discovery Chemistry (Peptide Synthesis)
Required skills
- siRNA
- peptide synthesis
- peptide analysis
- SPPS
- automated peptide synthesizers
- chromatography
- mass spectrometry
- HPLC
- LCMS
- macrocyclic peptides
Nice to have
- high throughput screening
- phage display
- mRNA display
- DEL
- OBOC
- biophysical assays
Role summary
Arrowhead is seeking a motivated Scientist III in Discovery Chemistry at its San Diego site, focusing on peptide synthesis and analysis for siRNA-based therapeutics. The role involves designing, executing, and troubleshooting peptide synthesis workflows, purifying and analyzing peptides using chromatography and mass spectrometry, and analyzing data to guide compound design. Collaboration with cross-functional teams is key to advancing delivery platform development. Requires a PhD (0-2 years experience) or Master's (5+ years experience) in chemistry, with hands-on experience in automated peptide synthesis and characterization of complex peptides. Proficiency in HPLC, LCMS, and strong problem-solving skills are essential.
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a highly motivated Scientist to join our discovery chemistry team at its San Diego site. The successful candidate will primarily focus on peptide synthesis and analysis. As a discovery chemist, you will play a pivotal role in the development and optimization of siRNA-based therapeutics by leveraging your expertise in peptide chemistry.
This role is onsite 5 days a week in San Diego.
Responsibilities
Requirements
Preferred
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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