Biotechnology, Life Sciences, Research & Development

Associate Director/Director, Biostatistics

South San Francisco, CAOnsiteFull TimeDirector$235,000–$300,000 /yrPosted 23 days agoVisa sponsorship available

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Required skills

biostatistics
clinical programs
statistical data analysis
clinical development
study design
protocol
endpoint selection
sample size
evidence-generation
adaptive designs

Nice to have

external control groups
natural history studies
patient registries
systematic literature reviews
computational biology
pharmacology

Role summary

Calico, an Alphabet-founded research company focused on human aging, seeks an Associate Director/Director of Biostatistics. This role provides statistical expertise and leadership for clinical programs, supporting drug development from early phases through regulatory submissions. Responsibilities include developing statistical strategies, evaluating trial designs (including adaptive and Bayesian methods), and collaborating with cross-functional teams. The position requires a Ph.D. or M.S. in Biostatistics/Statistics with significant relevant experience, strong leadership skills, and experience managing external vendors. Preferred experience includes rare disease research and specific study methodologies. The role requires onsite work at least 4 days a week.

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, academic and industry partners, and vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

The Associate Director or Director of Biostatistics will be responsible for providing statistical data analysis expertise and leadership to support assigned clinical programs. Calico provides a scientifically stimulating and collaborative working environment, and this role will interact with scientists from a range of disciplines including basic research, computational biology, pharmacology, PKPD and biomarker experts. We are seeking a creative and innovative statistical scientist to direct project teams towards efficient strategies for data integration across multiple platforms with the ultimate goal of deriving meaningful inferences about the human condition.

Key Responsibilities:

Independently lead biostatistical support for assigned therapeutic programs and clinical studies across development phases

Develop statistical strategies aligned with clinical development objectives and regulatory requirements

Collaborate with clinical and scientific teams to evaluate study design alternatives, assess risks and uncertainties, and support data-driven development decisions

Provide statistical input into clinical development plans, study protocols, endpoint selection, sample size considerations, and overall evidence-generation strategies

Develop and evaluate innovative trial designs, including adaptive designs, Bayesian approaches, and simulation-based methods, as appropriate

Provide statistical expertise for studies involving small sample sizes, heterogeneous patient populations, rare diseases, and limited clinical data

Communicate statistical concepts, assumptions, limitations, and implications clearly to cross-functional teams

Position Requirements:

Ph.D. in Biostatistics/Statistics or equivalent with at least 8+ years’ relevant work experiences or M.S. in Biostatistics/Statistics with at least 10+ years’ relevant experience

Broad and thorough understanding of statistical principles and clinical trial methodology; able to practice and implement them

Ability to develop innovative/creative statistical/technical solutions to complex problems

Leadership skills in priority evaluation, adapting to changes, conflict resolution, and effective partnership

Ability to work independently, exercise sound scientific judgment, and manage multiple competing priorities

Experience managing CROs, external statistical consultants, and statistical programming vendors

Experience with NDA or other major regulatory submissions

Excellent written and verbal communication skills, including the ability to communicate statistical concepts to non-statistical stakeholders

Experience supporting rare disease or other indications with small patient populations and limited clinical data is preferred

Experience with external control groups, natural history studies, patient registries, or systematic literature reviews is preferred

Must be willing to work onsite at least 4 days a week

The estimated base salary range for this role is $235,000 - $300,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

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Associate Director/Director, Biostatistics

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Required skills

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