Senior Research Associate / Associate Scientist, Nonclinical

Alltrna is looking for a hands-on scientist to join our Nonclinical team, where we test how well our engineered tRNAs work across a range of preclinical disease models. The ideal candidate is a strong cell and molecular biologist who is detail-oriented, intellectually curious, and energized by being part of a collaborative, fast-paced, small-company environment.

Working closely with the Nonclinical team, this individual will select, develop, and optimize the assays we use to measure tRNA activity and efficacy. These include cell-based assays in primary cells and hepatocyte models to the RNA and protein readouts that support in vivo studies. The candidate will design, execute and analyze data that support platform expansion and drive early-stage programs into clinical development. This role will have opportunities to propose new ideas, collaborate with groups across the company and participate in broader data reviews and decision-making.

We are hiring at the Senior Research Associate or Associate Scientist level, depending on experience. We are looking for someone who takes ownership of their experiments, works carefully and efficiently, and can troubleshoot technical challenges and adapt to changing priorities while maintaining scientific rigor.

Key Responsibilities:

Key Qualifications:

Preferred Qualifications

About Alltrna

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affects approximately 10% of people with a rare genetic disease. Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics.

For more information, visit www.alltrna.com

The salary range for this role is $81,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

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