Medical Director: Gastroenterology, Pulmonary, Rheumatology, Nephrology
Required skills
- M.D
- Immunology
- Inflammation
- Biomarker
- Safety Data
- Asset Strategy
- Clinical Protocol
- Medical Monitor
- GCP
- ICH
Nice to have
- M.D./Ph.D
Role summary
Genentech's Early Clinical Development (ECD) OMNI group seeks a Medical Director to drive innovation in immunology indications. This role involves designing early-phase clinical trials (Phase I/II), providing medical oversight and safety monitoring, and leading cross-functional strategy. The Medical Director will also author regulatory documents, interact with global health authorities (FDA, EMA), and engage with Key Opinion Leaders (KOLs). The ideal candidate is an M.D. with board certification in relevant specialties (Gastroenterology, Pulmonary, Rheumatology, Nephrology), possessing 2+ years of research experience in immunology or inflammation, and a strong understanding of early clinical drug development principles, GCP/ICH guidelines, and clinical data interpretation. Excellent scientific communication and collaboration skills are essential.
The Position
We advance science so that we all have more time with the people we love.
The Early Clinical Development (ECD) OMNI group at Genentech drives innovation across a broad portfolio of immunology indications, advancing breakthrough science from First-in-Human studies through Proof-of-Concept and initial pivotal decisions. Driven by gRED’s mission to make fundamental scientific discoveries and help develop them into best-in-class therapeutics that provide unique benefits to patients, our team translates complex biology into transformative therapies.
The Opportunity:
Drive Clinical Trial Design: Author clinical protocols and design early-phase (Phase I/II) studies to establish biologic and clinical proof-of-concept for novel molecular entities (NMEs).
Serve as Medical Monitor: Provide medical oversight, safety monitoring, and clinical expertise across active trials while collaborating with trial sites, investigators, and CROs.
Lead Cross-Functional Strategy: Represent Clinical Science on multi-disciplinary Clinical Science Teams (CST) and Protocol Execution Teams (PET), integrating insights across biomarkers, safety, regulatory, and commercial functions.
Guide Regulatory & Asset Strategy: Author clinical sections for INDs, IBs, and health authority briefing materials, supporting direct interactions with global regulatory bodies (FDA, EMA).
Engage Global Scientific Leaders: Collaborate with internal research groups, external Key Opinion Leaders (KOLs), and scientific advisory boards to refine disease area strategies and inform portfolio decisions.
Who You Are:
Clinical Expertise: M.D. with Board Certification or eligibility in Gastroenterology, Pulmonary, Rheumatology, Nephrology, or a related specialty (M.D./Ph.D. preferred).
Research Track Record: 2+ years of clinical, translational, or basic research experience within academia or the biopharmaceutical industry, with a demonstrated focus on immunology or inflammation.
Development Acumen: Thorough understanding of early clinical drug development principles (Phases I–II), trial methodology, GCP/ICH guidelines, and sophisticated clinical data interpretation.
Strategic & Collaborative Mindset: Adept at synthesizing complex biomarker and safety data to shape asset strategy and influence decisions across cross-functional matrix teams.
Scientific Communicator: Highly effective communicator capable of building strong collaborative networks with academic investigators, regulatory bodies, and internal research partners.
Relocation benefits are available for this posting.
Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week.
The expected salary range for this position based on the primary location of South San Francisco, California is $213,400 - $396,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
#ECD
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
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