Biotechnology, Pharmaceuticals, Life Sciences

Sr. Manager or Associate Director or Director, Biostatistics

Watertown, MAOnsiteFull TimeDirector$160,000–$275,000 /yrPosted 2 months agoVisa sponsorship available

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Required skills

Biostatistics
clinical trial
biotechnology
pharma
SAS
FDA
EMA
ICH guidelines
statistical methods
clinical protocols

Nice to have

Python
EAST
nQuery
continuous improvement

Role summary

Kymera Therapeutics, a clinical-stage biotechnology company focused on targeted protein degradation (TPD), seeks a Sr. Manager or Associate Director or Director, Biostatistics. This role will lead statistical efforts for clinical studies/programs, contributing to development plans, regulatory submissions, and data strategy. Responsibilities include authoring statistical sections of documents, developing analysis plans, overseeing CROs, and ensuring compliance with global regulatory standards. The position requires an advanced degree in Statistics or related field with at least 6 years of clinical trial experience, extensive knowledge of statistical methods, and expertise in SAS. Familiarity with R, Python, and trial design software is advantageous. Strong communication and analytical skills are essential, with potential for direct report management.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.

How we work:

PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.

COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.

BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As the Study/Program Lead Statistician, you will spearhead the statistical efforts of a clinical study/program playing a key role in the clinical development plan, regulatory submissions, and overall data strategy. This role requires strategic involvement in program teams, authorship of statistical sections in study documents, and direct oversight of outsourced statistical functions.

Act as the lead statistician of a clinical study or program, leading statistical efforts and representing biometrics functions on study/program teams. Make strategic contributions to the clinical development plan.

Contribute to regulatory submissions and inspections, ensuring compliance with global regulatory standards.

Contribute to the development of clinical protocols by authoring the statistical methods section and reviewing other sections for statistical accuracy.

Develop and review statistical analysis plans for individual studies and integrated summaries of safety/efficacy (ISS/ISE). Create and edit statistical outputs shells.

Provide statistical input during CRF design to ensure alignment with study objectives and analyze requirements. Oversee and quality control results from statistical programmers or CROs.

Contribute to clinical study reports by authoring statistical sections and interpreting study results. Support the preparation of scientific publications and presentations.

Manage relationships with CROs to ensure high-quality statistical outputs and compliance with study requirements.

May manage direct reports, as needed, providing guidance and professional development.

Skills and experience you’ll bring:

Advanced degree in Statistics or related field with minimum 6 years of clinical trial experience in a biotechnology or pharma company.

Extensive knowledge of statistical methods for clinical trials and deep familiarity with FDA, EMA, and ICH guidelines.

Expertise in SAS required; R or Python is advantageous. Experience with trial design software such as EAST or nQuery.

Strong communication skills necessary for effective collaboration with cross-functional teams. Ability to communicate statistics to non-statisticians effectively; influence and ensure adoption of robust statistical methods.

Exceptional ability to manage multiple priorities in a fast-paced environment.

A strong passion for innovation in Biostatistics and continuous improvement in processes.

Strong analytical and problem-solving abilities.

Positive attitude and a collaborative spirit.

Equal Employment Opportunity

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.

The anticipated base salary range for this role is $160,000– $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.

Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

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