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Nurix Verified
Biotechnology, Pharmaceuticals

Scientist I, Medicinal Chemistry

The Woodlands, TXOnsiteFull Time$130,200–$141,400 /yrPosted 26 days agoVisa sponsorship available

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Required skills

  • synthetic organic chemistry
  • complex synthesis
  • multistep synthesis
  • troubleshoot
  • chemistry
  • scientific curiosity
  • learn new concepts
  • collaborative
  • multidisciplinary
  • research environment

Nice to have

  • targeted protein degradation
  • AI-integrated discovery engine
  • ligase expertise

Role summary

Nurix Therapeutics is seeking a Scientist I, Medicinal Chemistry to design and synthesize novel small molecules for patients with unmet medical needs. This role involves applying structure-based drug design, supported by computational and structural biology teams, within a multidisciplinary project team. The ideal candidate will have a PhD with up to 4 years of relevant experience, or an MS with 6+ years, or a BS with 10+ years. Key responsibilities include designing and executing complex organic syntheses, troubleshooting chemistry challenges, advancing SAR studies, and collaborating with various scientific disciplines. Strong communication and teamwork skills are essential. Experience in targeted protein degradation is preferred.

Scientist I, Medicinal Chemistry

Join Nurix's medicinal chemistry group to design and synthesize novel small molecules for patients with unmet medical needs. You'll apply structure-based drug design, supported by our computational and structural biology teams, as part of a dynamic, multidisciplinary project team.

Position Description

The Opportunity

  • Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy, using modern synthetic methods and creative strategies to access challenging molecules
  • Engage in rational structure-based drug discovery enabled by our computational and structural biology group
  • Apply strong problem-solving skills to troubleshoot challenges and identify practical solutions
  • Design and execute high-quality experiments, critically analyze results, and use data to form hypotheses and guide next steps
  • Advance structure-activity relationship (SAR) studies by contributing to compound design
  • Collaborate with scientists in computational chemistry, structural biology, biochemistry and biophysics, cellular biology, pharmacology, DMPK, and toxicology, as well as external collaborators, to integrate multidisciplinary data and advance project objectives
  • Stay current with advances in synthetic and medicinal chemistry and apply relevant methods to project work
  • Communicate scientific rationale, results, challenges, and recommendations clearly to chemistry colleagues and cross-functional project teams

    • What You’ll Bring

  • PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience
  • Strong expertise in synthetic organic chemistry, with demonstrated ability to design and execute complex, multistep organic synthesis
  • Strong scientific and synthetic problem-solving skills and the ability to independently troubleshoot challenging chemistry
  • Scientific curiosity, creativity, and the ability to rapidly learn and apply new concepts, technologies, and approaches
  • Strong interpersonal and teamwork skills, with demonstrated ability to contribute in a collaborative, multidisciplinary research environment
  • Excellent written and verbal communication skills, with the ability to clearly communicate scientific concepts, results, and conclusions
  • Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK, consistent with prior experience

    • Salary Range: $130,200 - $141,400

    The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

    Location: Onsite – The Woodlands, TX

    Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

    • About Nurix Therapeutics

    Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

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