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Sail Biomedicines Verified

Scientist, Platform RNA Sciences

Cambridge, MAOnsiteFull Time$98,000–$125,000 /yrPosted 2 months agoVisa sponsorship available

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Required skills

  • programmable medicines
  • circular RNA technology
  • Endless RNA™
  • eRNA
  • nanoparticles
  • AI techniques
  • hypothesis-driven experiments
  • high-throughput screens
  • RNA biology
  • RNA purification

Nice to have

  • library preparation
  • ribozyme
  • aptamer
  • complex RNA structures

Role summary

Sail Biomedicines is seeking a Scientist, Platform RNA Sciences to advance its programmable circular RNA technology (Endless RNA™ or eRNA). This role involves designing and conducting experiments, including high-throughput screens, to optimize eRNA designs for improved circularization, stability, and translation. Responsibilities include performing molecular and biochemical techniques, analyzing data using various tools, and documenting findings. The ideal candidate will have a strong background in RNA biology, molecular biology, or biochemistry, with experience in techniques like IVT, RNA purification, RT-qPCR, and RNA-seq. Preferred qualifications include NGS library preparation and experience with ribozyme or aptamer engineering. The role requires excellent problem-solving, data analysis, and communication skills.

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

The Scientist, Platform RNA Sciences, will work on key projects to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role works cross-functionally to perform hypothesis-driven experiments and high-throughput screens to improve our eRNA designs, with the goal to maximize circularization, and enhance RNA stability and translation. The successful candidate is self-motivated, curious and creative, thinks outside of the box and has a can-do mindset. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.

Responsibilities

  • Conceive and conduct pooled and array screens to improve our eRNA designs, enabling higher product purity and function
  • Design hypothesis-driven experiments based on state-of-the-art RNA biology to refine our eRNA designs
  • Evaluate and develop alternative circularization strategies
  • Determine circularization efficiency and impurity levels by running analytic assays
  • Design properly controlled experiments, generate high-quality data, and run rigorous statistical analysis
  • Maintain detailed documentation in electronic lab notebooks
  • Author standard operating procedures (SOPs), study summaries, and technical reports
  • Present findings clearly in oral or written formats to internal and external stakeholders to enable alignment and decision-making

    • Qualifications

  • Ph.D. in Molecular Biology, Biochemistry, or a related field, or M.S. with 6+ years of focused, full-time research experience in RNA technologies
  • Strong background in RNA biology with demonstrated skillset in relevant molecular and biochemical techniques, such as in vitro transcription (IVT), RNA purification, oligo-dT purification, column chromatography, capillary gel electrophoresis, RT-qPCR, RNA-seq, Nanopore sequencing
  • Experience using data analysis and information management tools, such as Excel, Graphic Prism, R, JMP, SnapGene, Benchling, Smartsheet, Jira
  • Excellent problem-solving skills with the ability to independently design and carry out experiments
  • Ability to manage multiple tasks at once while knowing how to prioritize
  • Strong collaborative spirit and excellent organizational and communication skills
  • Excellent record keeping

    • Preferred Qualifications

  • Experience in Next Generation Sequencing (NGS) library preparation
  • Working knowledge in engineering ribozyme, aptamer or other complex RNA structures

    • Salary Range: $98,000 - $125,000

    Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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