Manager, HR Business Partner

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Reporting to the CHRO, the Manager, Human Resources Business Partner (HRBP) supports the General & Administrative (G&A) functions, partnering with leaders and employees across areas such as Finance, Legal, IT, and HR, as applicable. The HRBP provides practical HR guidance, builds effective relationships, and helps implement people programs aligned with functional needs and company priorities. The role supports talent and career development, manager coaching, employee relations, performance management, and organizational change. The Manager independently handles routine HR matters and partners with the CHRO on complex, sensitive, or higher-impact decisions.

Your Role:

Serves as the primary day-to-day HR partner for assigned G&A teams, providing timely guidance and delivering HR programs and services in support of functional priorities

Uses HR data, employee feedback, and knowledge of G&A operations to identify people trends, highlight concerns, and recommend practical actions; escalates significant issues and recommendations to the CHRO

Implements and improves HR processes and solutions in partnership with the CHRO and HR colleagues, recommending changes based on client needs

Supports leaders with team effectiveness, role clarity, and organizational changes; partners with the CHRO on complex organization design or sensitive change initiatives

Partners with G&A leaders to identify talent needs and implement practical approaches to employee development, engagement, and retention

Supports annual workforce and headcount planning for G&A functions, including identifying hiring needs, skills gaps, and succession considerations; contributes analysis and recommendations for CHRO and functional leader review

Collaborates closely with HR colleagues to deliver consistent employee experiences and implement company-wide HR programs across the G&A client group

Coordinates performance and talent processes for G&A teams, including ongoing feedback, performance discussions, calibration, and compensation planning in partnership with the CHRO and relevant HR colleagues

Partners with Talent Acquisition and G&A hiring managers to clarify role requirements, support hiring plans, and facilitate onboarding and integration

What You Bring:

Education and Experience:

Undergraduate degree in human resources or related, relevant discipline

Typically requires 5–7 years of progressive HR experience, including experience supporting leaders as an HR generalist or HR business partner, or an equivalent combination of education and experience

Knowledge and Skills:

Experience implementing HR programs and advising managers on day-to-day people matters

Experience supporting headcount planning, talent reviews, or workforce planning activities

Working knowledge of talent management, performance management, succession planning, and employee development

Experience supporting organizational change, employee engagement, or team effectiveness initiatives

Sound knowledge of manager coaching, employee relations, and HR data analysis; ability to recognize when to escalate complex or sensitive matters

Traits and Qualities:

Ability to influence positively including in situations without direct authority

Ability to manage routine responsibilities independently while seeking guidance on complex, sensitive, or precedent-setting matters; collaborates effectively across teams

Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines

Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task

Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders

Outstanding interpersonal and communication abilities with a high degree of emotional intelligence

Demonstrates sound judgment, discretion, and interpersonal skills to build credibility with employees and G&A managers

Have proven communication skills, both written and verbal, and the ability to present information clearly to a variety of audiences

Able to learn quickly, organize work, and execute defined HR projects with appropriate guidance and follow-through

Thrives in high energy and fast paced organization with ongoing simultaneous initiatives

Builds alignment through clear communication, collaboration, and practical recommendations

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $108,800—$136,000 USD