Associate Director, Operational Excellence

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

The Operational Excellence and Training Lead enables scalable, efficient, and inspection‑ready execution across Development by designing standardized processes, building operational capabilities through training, and driving consistent adoption and continuous improvement.Your Role:

Own and lead end‑to‑end design, implementation, and optimization of assigned process and system across Development

Translate strategic objectives into fit‑for‑purpose, standardized processes that are efficient, scalable, and inspection‑ready

Define process standards, guidance, and performance measures, ensuring clarity of roles and accountability

Develop and deliver training on new/changed processes incl. compliance expectations, and inspection readiness behavior

Design and maintain role‑based and process‑based curricula, including onboarding

Identify inefficiencies, risks, and variability through data analysis and stakeholder input, and lead targeted improvement initiatives

Support functions in adopting new or improved processes through change management, training inputs, and practical guidance

Ensure processes are well documented, consistently applied, and auditable, supporting inspection readiness

Track and report process performance, improvement outcomes, and residual risks to Operational Excellence & Clinical Compliance leadership

Act as a subject‑matter expert and trusted advisor to functional teams on process excellence and operational rigor

Support Leadership in defining and executing the learning and capability‑building strategy for Development functions

Support leadership in building a learning culture that reinforces accountability, consistency, and continuous improvement

What You Bring:

Required Qualifications

Bachelor’s degree required (Life Sciences, or related field)

Advanced degree preferred (e.g., MBA, MSc)

Certification or formal training in Operational Excellence, Lean, Six Sigma, or Process Improvement preferred

Required Experience

8–10+ years’ experience in operational excellence, process improvement, training, or operational leadership within a regulated life sciences or clinical development environment

Proven experience owning and implementing end‑to‑end processes or systems across multiple functions

Hands‑on experience designing and delivering process and role‑based training

Experience supporting audit and inspection readiness, including documentation and behavioral readiness

Required Competencies

End‑to‑end process design, standardization, and optimization

Lean / continuous improvement methodologies

Training design, curriculum development, and adult learning principles

Process documentation (SOPs, guidance, work instructions)

Process performance metrics, KPIs, and dashboarding

Understanding compliance and inspection expectations in regulated environments.

Strong systems thinker able to translate strategy into execution

Excellent facilitation, communication, and stakeholder‑engagement skills

Ability to influence and drive adoption without direct authority

Pragmatic change leader with strong execution discipline

Trusted advisor mindset with high credibility and accountability

Collaborative, service‑oriented, and improvement‑focused

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $164,000—$246,000 USD