Twist Bioscience Verified

Biotechnology, Life Sciences, Synthetic Biology, Genomics

Applications Lab Associate II

Name: RiseMe
Availability: InStock

South San Francisco, CAOnsiteFull Time$116,000–$135,000 /yrPosted 1 month agoVisa sponsorship available

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Required skills

NGS
Next Generation Sequencing
library preparation
target enrichment
sequencing workflows
PCR
qPCR
DNA quantification
DNA purification
SPRI

Nice to have

Illumina
PacBio
Element
ONT
DNA assays
RNA assays

Role summary

Twist Bioscience is seeking a motivated Applications Lab Associate II to support customer-driven Next Generation Sequencing (NGS) projects in a service laboratory. This role involves executing NGS library preparation, target enrichment, and sequencing workflows, processing samples, and performing molecular biology techniques like PCR and DNA purification. The associate will operate lab equipment, troubleshoot issues, maintain documentation, analyze data, and ensure compliance with quality standards. Collaboration with cross-functional teams under tight deadlines is essential. A BS/MS in a related field and hands-on molecular biology experience are required, with preferred qualifications including 3-5 years of NGS experience and familiarity with specific NGS platforms and analytical tools.

Twist Bioscience is seeking a highly motivated and detail-oriented individual to support customer-driven Next Generation Sequencing (NGS) projects within a fast-paced, service laboratory. This role will work cross-functionally with Sales, R&D, Field Applications, and Customer Support teams to deliver high-quality sequencing data and solutions. The ideal candidate thrives in a dynamic environment, is highly organized, and is committed to maintaining production timelines while ensuring scientific excellence.

What You’ll Be Doing

Execute NGS library preparation, target enrichment, and sequencing workflows according to established protocols

Process samples for NGS analysis while meeting production schedules and customer timelines

Perform routine molecular biology techniques including PCR/qPCR, DNA quantification, purification (e.g., SPRI), and electrophoresis

Operate and maintain laboratory equipment, including liquid handling robots and sequencing platforms

Troubleshoot experimental and equipment-related issues to ensure continuity of workflows

Track multiple projects and samples simultaneously, ensuring accurate and detailed documentation (including batch records and deviations)

Analyze experimental data and contribute to interpretation of results

Support development, optimization, and execution of NGS-related protocols and workflows

Maintain digital files and records associated with sequencing runs

Ensure compliance with regulatory standards (e.g., ISO 13485) and internal quality requirements

Support general lab operations including cleaning, restocking, and maintaining a well-organized workspace

Collaborate effectively with cross-functional teams under aggressive timelines

What You’ll Bring to the Team

B.S. or M.S. in Molecular Biology, Biochemistry, Chemistry, or a related field (Associates degree with relevant experience may be considered)

Hands-on experience in molecular biology techniques such as PCR, DNA purification, quantification, and library preparation

Experience working in a laboratory environment with strong attention to detail and documentation practices

Ability to manage multiple tasks and prioritize effectively in a fast-paced environment

Strong organizational, planning, and problem-solving skills

Excellent interpersonal and communication skills with a collaborative mindset

Self-motivated with a commitment to delivering high-quality results

Preferred Qualifications

3–5 years of experience in molecular biology, NGS workflows, or a related field

Direct experience with NGS platforms (e.g., Illumina, PacBio, Element, ONT) and associated sample preparation workflows

Experience with NGS library preparation and target enrichment workflows

Experience with a range of NGS applications DNA, RNA, and Methylation assays

Strong familiarity with analytical tools such as BioAnalyzer or TapeStation, Qubit fluorometry and Nanodrop spectrophotometry

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.San Francisco Bay Area Pay Range$116,000—$135,000 USD

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