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Biotechnology, Artificial Intelligence, Drug Discovery, Machine Learning

Senior Scientist, High Throughput Biology (Contract)

South San Francisco, CAOnsiteContractSeniorPosted 10 days agoVisa sponsorship available

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Required skills

  • Immunology
  • Molecular Biology
  • Cell Biology
  • Biochemistry
  • Functional Genomics
  • high-throughput screens
  • drug discovery
  • development efforts
  • binder discovery
  • mammalian systems

Nice to have

  • yeast display
  • phage display
  • mammalian display
  • single-cell genomics workflows
  • scRNA-seq
  • barcoded assays

Role summary

Xaira Therapeutics is seeking a Senior Scientist for a 9-month contract role focused on high-throughput biology to accelerate drug discovery. The position requires leading the design and execution of experiments using functional genomics and synthetic biology, developing high-throughput screens, and piloting new technologies. Responsibilities include optimizing assays, scaling screening strategies, developing automated workflows, analyzing data, and managing projects. Qualifications include a Ph.D. in a relevant scientific field with 4+ years of experience, proficiency in molecular biology techniques, flow cytometry, cell line engineering, NGS, and data analysis software. Experience with antibody display technologies and single-cell genomics is a plus. The role involves mentoring junior scientists and requires strong communication and collaboration skills.

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

We are seeking an accomplished Senior Scientist to join our team at Xaira Therapeutics on a contract basis. In this role, you will lead the design and execution of innovative experiments that accelerate our drug discovery and development efforts, applying functional genomics and synthetic biology approaches, developing high-throughput screens, and driving new technology initiatives. The successful candidate will bring deep technical expertise and strong laboratory skills, communicate effectively in writing and in person, and work productively in a collaborative, cross-functional environment. You will also mentor junior scientists and stay current with the relevant literature and emerging technologies in the field.

This is a contract position with an anticipated duration of approximately 9 months.

Key Responsibilities

  • Lead the design, implementation, and optimization of biochemical, molecular, and cell-based assays to support high-throughput screening platform development.
  • Scale high-throughput screening strategies for binder discovery in mammalian systems.
  • Evaluate and pilot emerging technologies and experimental workflows to strengthen discovery capabilities, and make recommendations on their adoption.
  • Develop and optimize automated workflows, ensuring data quality, reproducibility, and process efficiency.
  • Partner with drug discovery, computational biology, and AI-based protein design teams to analyze, interpret, and share insights from screening data.
  • Independently manage multiple projects, ensuring timely delivery of high-quality data and alignment with team goals.
  • Maintain accurate records of experiments, protocols, and findings, and contribute to internal and external scientific presentations.

    • Qualifications

  • Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or a related field, with 4+ years of postdoctoral or industry experience.
  • Candidates with fewer years of experience are encouraged to apply and the title can be adjusted accordingly.
  • Proficiency with molecular biology techniques, complex library construction, flow cytometry, and cell line engineering.
  • Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC.
  • Experience with high-throughput antibody display technologies, including yeast, phage, or mammalian display, is a plus.
  • Familiarity with single-cell genomics workflows (e.g., scRNA-seq, barcoded or multiplexed assays) is a plus.
  • Demonstrated ability to troubleshoot complex experimental issues independently and to guide others through them.
  • Strong data analysis capabilities, including proficiency with visualization and statistical software (e.g., GraphPad Prism, R, Python).
  • Excellent written and verbal communication skills, with the ability to present scientific findings clearly and concisely to diverse audiences.
  • Collaborative team player who can work effectively across interdisciplinary teams and drive cross-functional projects.
  • Track record of scientific contributions, such as publications, patents, or internal technology development.

    • Employment Type: Contract

    Expected Contract Duration: 9 Months

    The base pay range for this position is expected to be $65-$80 hourly; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

    Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

    TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

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