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Biotechnology, Artificial Intelligence, Drug Discovery, Machine Learning

Senior Scientist Single Cell Assay and Technology Development

South San Francisco, CAOnsiteFull TimeSenior$136,000–$170,000 /yrPosted 17 days agoVisa sponsorship available

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Required skills

  • single-cell
  • AI-driven drug discovery
  • molecular readouts
  • high-throughput
  • NGS library preparation
  • QC
  • mammalian cell systems
  • cell engineering
  • flow cytometry
  • imaging

Nice to have

  • antibody engineering
  • immunology
  • primary immune cell assays
  • high-throughput assays
  • miniaturized assays
  • lab automation

Role summary

Xaira Therapeutics is seeking a Senior Scientist to invent and develop single-cell assays for AI-driven drug discovery. This role involves creating new molecular readouts and scaling commercial technologies to measure cellular states. The scientist will own assay development from concept to reproducible workflows, contributing to the technical direction of a multidisciplinary team. Responsibilities include prototyping novel assays, developing assay components, building mammalian cell systems, and collaborating with biologists and engineers. The role requires expertise in molecular biology, NGS, single-cell sequencing, mammalian cell biology, assay development, experimental design, and statistical analysis, with proficiency in R or Python. A PhD and 4+ years of relevant experience are required.

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

As a Senior Scientist on Xaira’s High-throughput Biology team, you will invent and develop single-cell assays for AI-driven drug discovery. You will create new molecular readouts and extend commercial and published technologies to measure cellular state and responses at scale. You will own development from concept and feasibility through reproducible workflows for high-throughput data generation.

Join a small, multidisciplinary technology development team where you will shape technical direction. Working with biologists, engineers, and computational scientists, you will rapidly design, prototype, and test new assays. You will help decide which ideas to pursue, which technologies to adopt, and how to expand their capabilities. The assays you build will generate data that power Xaira’s machine-learning models.

Key Responsibilities

  • Conceive, prototype, and develop novel single-cell assays, and expand commercial workflows to enable new molecular readouts and biological applications.
  • Develop and troubleshoot assay components from sample preparation and barcoding through reverse transcription, amplification, targeted or whole-transcriptome NGS library preparation, and QC; design custom primers, oligonucleotides, and barcodes.
  • Build mammalian cell systems and functional assays using cell engineering, flow cytometry, imaging, and in situ hybridization.
  • Partner with biology and engineering teams to turn prototypes into reproducible, scalable workflows and document protocols for transfer to internal teams.
  • Evaluate emerging technologies.

    • Qualifications

  • PhD in molecular biology, cell biology, bioengineering, biochemistry, immunology, or a related field, with 4+ years of relevant experience, including industry experience in assay or technology development.
  • Candidates with fewer than 4 years of postdoctoral experience, with strong single-cell assay/technology development experience, are encouraged to apply. The title can be adjusted accordingly.
  • A track record of inventing or substantially improving single-cell, NGS, or cell-based assays.
  • Curiosity and the ability to learn unfamiliar techniques quickly and apply them to new assay concepts.
  • Expertise in molecular biology and NGS assay development, including nucleic acid handling, reverse transcription, enzymatic reactions, oligonucleotide design, and library preparation and QC.
  • Experience developing or adapting single-cell sequencing workflows, with strong troubleshooting and problem-solving skills across biology, assay chemistry, instrumentation, and data.
  • Strong mammalian cell biology skills, including cell culture and functional assay development.
  • Strong analytical skills in experimental design and statistical analysis of NGS and single-cell data; proficiency in R or Python.
  • Strong organizational skills and clear written and oral communication.
  • Ability to work effectively in a fast-paced, rapidly changing environment.

    • Preferred Qualifications

  • Antibody engineering, expression, QC, conjugation, or functional testing; immunology or primary immune cell assays.
  • High-throughput or miniaturized assays, lab automation, or design of experiments.
  • Pooled screening, genetic or chemical perturbation assays, or molecular reporter development with sequencing-based readouts.

    • Compensation

    We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $136,000 - $170,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

    Xaira Therapeutics is an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

    TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

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