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Xaira Therapeutics Verified
Biotechnology, Artificial Intelligence, Drug Discovery, Machine Learning

Senior Scientist, Biology

South San Francisco, CAOnsiteFull TimeSenior$140,000–$170,000 /yrPosted 2 months agoVisa sponsorship available

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Required skills

  • Immunology
  • ex vivo tissue systems
  • flow cytometry
  • high-parameter panel design
  • 15+ colors
  • ELISA
  • MSD
  • Luminex
  • qPCR
  • RNAseq analyses

Nice to have

  • AI tools
  • drug mechanisms
  • therapeutic program strategy
  • cross-functional collaborations
  • troubleshoot
  • record keeping

Role summary

Xaira Therapeutics is seeking a lab-based Senior Scientist in Inflammation and Immunology to join their Biology & Pharmacology department. This role involves hands-on research with primary human and mouse immune cells and ex vivo tissue systems to investigate disease biology and drug mechanisms. The scientist will design, execute, and analyze in vitro and in vivo studies, identify knowledge gaps, evaluate targets, and contribute to therapeutic program strategy. Key responsibilities include performing immune profiling via high-parameter flow cytometry and molecular assays (ELISA, Luminex, qPCR, RNAseq), and functional assays. The role requires a PhD in Immunology with 3+ years of experience, a strong publication record, expertise in flow cytometry panel design, and the ability to independently plan and interpret experiments. Familiarity with AI tools is preferred.

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the RoleXaira Therapeutics is seeking a lab-based Senior Scientist in Inflammation and Immunology to join our Biology & Pharmacology department. This role is ideal for someone who thrives in a hands-on research environment, has experience working with primary human and mouse immune cells, including ex vivo tissue systems, and is excited to help shape therapeutic program strategy.

In this role, you will investigate disease biology and drug mechanisms, generate actionable data, and intellectually contribute to advancing therapeutic programs through cross-functional collaborations.

What You’ll Do

  • Drive preclinical programs by designing, executing and analyzing in vitro and in vivo studies that explore disease biology, target validation, and lead candidate development.
  • Identify knowledge gaps, ask critical mechanistic questions to guide program direction, and evaluate novel targets and therapeutic strategies.
  • Dissociate human and mouse tissues into single-cell suspensions and/or establish tissue cultures for downstream functional or phenotyping assays including:
  • immune profiling, using high-parameter flow cytometry (15+ colors), and molecular tools (ELISA, MSD, Luminex, qPCR, RNAseq analyses).
  • functional assays (antigen presentation, immune cell activation, differentiation, proliferation, suppression, migration)
  • Translate experimental data into actionable insights and clearly communicate findings and recommendations to cross-functional teams.

    • What We’re Looking For

  • PhD in Immunology or a related field with 3+ years of relevant experience.
  • Track record of impact through first author publications, posters and presentations at meetings
  • Hands-on experience with primary human and mouse immune cells.
  • Strong expertise in flow cytometry, including high-parameter panel design, execution, and data analysis.
  • Proven ability to independently plan, execute, troubleshoot, and interpret experiments.
  • Excited about employing AI tools in every aspect of everyday work.
  • Highly organized and precise in record keeping, with the ability to manage multiple workstreams in a fast-paced environment.
  • Clear communicator who can distill complex data into actionable insights.

    • Compensation

    We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $140,000 - $170,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

    Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

    TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

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