Biotechnology, Life Sciences, Research & Development

Senior/Principal Associate Scientist, Mammalian Physiology

South San Francisco, CAOnsiteFull TimePrincipal$130,000–$161,000 /yrPosted 18 days agoVisa sponsorship available

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Required skills

in vivo studies
mammalian model systems
primary cell isolation
cell culture
biochemical assays
cellular assays
molecular assays
histology
immunofluorescence
data analysis

Nice to have

complex co-culture systems
organoids
biology
genetics
neuroscience

Role summary

Calico, an Alphabet-founded research and development company, is seeking a Senior/Principal Associate Scientist to join its Mammalian Physiology team. This role focuses on mammalian stress response pathways and disease, requiring a skilled experimentalist with strong critical thinking and communication abilities. The scientist will manage and coordinate in vivo studies, conduct primary cell culture assays, and analyze complex data. The ideal candidate will have 8+ years of experience with in vivo mammalian models (BS) or 6+ years (MS) and proficiency in various assays, histology, and immunofluorescence. Strong collaboration and independent execution skills are essential for meeting time-sensitive goals in a fast-paced environment.

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a Senior/Principal Associate Scientist to join an interdisciplinary, collaborative team working at the intersection of mammalian stress response pathways and disease. The ideal candidate will be a skilled experimentalist with exceptional critical thinking skills, strong communication skills across cross-functional teams, and a strong history of productivity in fast-paced work environments. This person will be able to work both independently and collaboratively and will be detail-oriented, organized, adaptable and self-motivated.

Key Responsibilities:

Manage and coordinate in vivo studies, in collaboration with the Research Physiology team

Independently conduct smaller in vivo studies

Sample preparation and management and execution of downstream assays

Lead development and execution of primary cell culture assays

Effectively communicate experimental results and project progress in various forums such as lab meetings

Position Requirements:

BS/MS degree in physiology, biology, genetics, neuroscience or a related field, with 8+ years (BS) or 6+ years (MS) of extensive experience with in vivo mammalian model systems

Proficiency in mammalian in vivo experiments and primary cell isolation and culture; familiarity with complex co-culture systems and/or organoids preferred

Experienced in deploying biochemical, cellular and molecular assays, histology and immunofluorescence

Excellent written and oral communication skills and highly organized with ability to multi-task

Demonstrated ability to analyze and interpret complex data

Versatile experimentalist with a track record of learning new skills quickly

Skilled collaborator who is able to work closely with different teams to achieve project goals

Ability to independently plan, execute and analyze experiments to meet time-sensitive goals

Basic statistical skills required

Preference for prior experience working with data software such as Prism

Must be willing to work on site 5 days a week

The estimated base salary range for this role is $130,000 - $161,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

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