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Biotechnology, Life Sciences, Research

Co-Op, Targeted Non-Viral Delivery

Cambridge, MAOnsiteInternshipPosted 5 days ago

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Required skills

  • automated non-viral delivery platform
  • producing tLNPs
  • automated microfluidic workcell
  • run high-throughput screens
  • ionizable lipids
  • targeting ligands
  • onboard new workflows
  • experiment types
  • increase screening throughput
  • ELN documentation

Nice to have

  • lipid nanoparticle formulation
  • microfluidics
  • drug delivery systems
  • automated systems
  • high-throughput screening platforms
  • protein characterization methods

Role summary

Lila Sciences is seeking a Co-Op to contribute to the development of an automated non-viral delivery platform, specifically focusing on improving the production and characterization of targeted lipid nanoparticles (tLNPs). The role involves hands-on work with tLNP production, developing new conjugation and purification methods, and applying these on an automated microfluidic system. The co-op will collaborate with a multidisciplinary team, performing bench science and operating automated lab systems. Responsibilities include formulating and characterizing tLNPs, running high-throughput screens, executing characterization assays, onboarding new workflows, and documenting methods and results in an ELN. A BSc or MSc in a relevant scientific or engineering field with wet-lab experience is required.

Your Impact at LILA

Lila is seeking a co-op to help build the automated non-viral delivery platform. The role focuses on improving an automated system for production and characterization of targeted lipid nanoparticles (tLNP).

Day-to-day work involves producing tLNPs to support ongoing experiments, developing new conjugation and purification methods for tLNPs, and applying those methods on the automated system.

The co-op works alongside chemists, biologists, automation engineers, and data scientists, with hands-on time across both bench science and automated lab systems.

What You'll Be Building

  • Formulate and characterize targeted LNPs on an automated microfluidic workcell
  • Run high-throughput screens of ionizable lipids and targeting ligands
  • Execute downstream characterization assays such as DLS, RiboGreen, and TNS
  • Onboard new workflows and experiment types onto the workcell
  • Test and document changes that increase screening throughput
  • Record methods, results, and observations in the ELN for reuse across teams

    • What You'll Need to Succeed

  • Pursuing a BSc or MSc in chemical engineering, biomedical engineering, pharmaceutical sciences, biology, or a related field
  • Hands-on wet-lab experience and comfort following detailed SOPs
  • Data analysis skills, with the ability to interpret results and iterate on experimental design
  • Clear written and verbal communication, including ELN documentation
  • Available for the full January co-op term, onsite at Alewife

    • Bonus Points For

  • Experience with lipid nanoparticle formulation, microfluidics, or other drug delivery systems
  • Familiarity with automated systems or high-throughput screening platforms
  • Familiarity with protein characterization methods
  • Working knowledge of bioanalytical techniques such as fluorescence spectroscopy and electrophoresis

    • About LILA

    Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.

    LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai.

    Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.

    We’re All In

    Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

    Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

    A Note to Agencies

    Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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