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Biotechnology, Epigenetic Reprogramming

Senior Scientist / Scientist, In Vivo Pharmacology

South San FranciscoOnsiteFull TimeSenior$130,000–$180,000 /yrPosted 2 months ago

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Required skills

  • pharmacology
  • physiology
  • biology
  • in vivo
  • PK/PD
  • efficacy
  • dose-response
  • rodent models
  • study design
  • protocol development

Nice to have

  • liver biology
  • hepatic disease models
  • hepatocyte-directed delivery
  • nucleic acid delivery
  • viral vector delivery
  • GLP-enabling

Role summary

NewLimit, a biotechnology company focused on extending human healthspan through epigenetic reprogramming therapeutics, seeks a Scientist/Senior Scientist of In Vivo Pharmacology. This role involves designing, executing, and interpreting in vivo studies (PK/PD, efficacy) in animal models to evaluate novel therapies. Responsibilities include developing animal models, overseeing CROs, analyzing data to inform pre-clinical decisions, and contributing to regulatory documentation. The position requires a Ph.D. in a relevant field and significant experience in in vivo pharmacology study design and execution, with a preference for candidates with expertise in liver biology, nucleic acid delivery, or machine learning.

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking a talented Scientist / Senior Scientist of In Vivo Pharmacology to join our Translational Sciences team. This critical role designs and executes in vivo studies to evaluate pioneering epigenetic reprogramming therapeutics across our entire portfolio. As a subject matter expert in nonclinical and PK/PD study design, you will lead in vivo pharmacology strategies, collaborate cross-functionally with therapeutic area teams, and directly drive therapeutic candidate selection.

As a Senior Scientist/Scientist on our team, you will:

  • Design, execute, and interpret in vivo pharmacology studies (PK/PD, efficacy, dose-response) across multiple disease models and therapeutic programs
  • Collaborate with Epigenetic Editing, Predictive Modeling, and other therapeutic area teams to evaluate epigenetic reprogramming payloads in relevant animal models
  • Develop and refine animal models of aging and age-related disease to support translational studies
  • Oversee study design, protocol development, and CRO/vendor relationships for in vivo studies
  • Analyze and interpret in vivo data (PK/PD, biomarkers, functional endpoints) to drive pre-clinical decision making
  • Contribute to regulatory-enabling study design and documentation as programs progress toward clinical

    • Requirements

  • Ph.D. in pharmacology, physiology, biology or a related field or equivalent industry experience (5+ years for Scientist; 8+ years for Senior Scientist)
  • Demonstrated experience designing and executing in vivo pharmacology studies (PK, PD, efficacy, dose-range finding) in rodent models
  • Experience with study design, dosing regimens, and route-of-administration selection
  • Experience analyzing and interpreting in vivo pharmacology data to inform program decisions
  • Experience leading project workflows and providing technical mentorship to junior laboratory staff
  • History of contributing to a drug development program at the pre-clinical or clinical development stage

    • Nice to have

  • Experience with liver biology, hepatic disease models, or hepatocyte-directed delivery
  • Experience with nucleic acid or viral vector delivery in vivo
  • Experience with GLP-enabling or IND-enabling study design
  • Experience with single cell genomics or pooled screening approaches applied to in vivo readouts

    • Benefits

    NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site

    • Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

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