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Biotechnology, Epigenetic Reprogramming

Senior/Research Associate, mRNA Engineering

South San FranciscoOnsiteFull Time$75,000–$100,000 /yrPosted 18 days ago

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Required skills

  • M.S. in Life Sciences
  • molecular biology techniques
  • cloning
  • nucleic acid purification
  • PCR
  • gel electrophoresis
  • documentation practices
  • execute protocols accurately
  • mRNA process science

Nice to have

  • plasmid DNA preparation
  • linearization
  • column-based purification
  • automation liquid handling
  • Hamilton
  • Tecan

Role summary

NewLimit is a biotechnology company focused on extending human healthspan by developing medicines to treat age-related diseases through epigenetic reprogramming. They are seeking a Research Associate for their mRNA Engineering team to produce research-grade mRNA materials. This lab-based role involves executing protocols for DNA template preparation, in vitro transcription (IVT), and downstream purification, as well as running analytical assays. The associate will maintain detailed records, manage inventory, and collaborate with cross-functional teams. The position is ideal for an early-career scientist interested in mRNA process development, offering hands-on training and direct impact on research programs.

About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

We are seeking a Research Associate to join our mRNA Engineering team. In this role, you will generate the mRNAs that power NewLimit's research programs, executing the workflow from DNA template through in vitro transcription (IVT) and downstream purification. You will produce research grade mRNA materials, keep rigorous records of how each batch was made, and work closely with scientists across our research and Delivery Sciences teams. This is a lab-based role ideal for an early-career scientist who wants to build deep expertise in mRNA process development in a fast-paced research environment. You will receive hands-on training from expert scientists and see the direct impact of your work on our programs.

What you'll do

As a member of our team, you will:

mRNA production

  • Execute established protocols for DNA template preparation, in vitro transcription, and downstream purification to generate research-grade mRNA
  • Run routine analytical assays to assess mRNA integrity and purity
  • Under the guidance of senior scientists, help troubleshoot production issues and contribute to experiments that optimize yield, purity, and recovery

    • Documentation and lab operations

  • Maintain detailed, accurate records of all experiments in Electronic Lab Notebooks
  • Follow and help maintain SOPs; contribute to drafting and updating protocols as workflows evolve
  • Manage raw material and mRNA inventory, including sample tracking, storage, and reagent ordering
  • Maintain lab equipment and follow lab safety practices

    • Collaboration

  • Work closely with Delivery Sciences and research teams to coordinate material needs and hand off mRNA for downstream studies
  • Present experiment results at team meetings

    • Requirements

  • B.S. in Life Sciences, Chemistry, Engineering, or a related field with 1-2 years of relevant full-time industry or academic research experience, or M.S. in Life Sciences
  • Hands-on experience with molecular biology techniques such as cloning, nucleic acid purification, PCR, and gel electrophoresis
  • Strong attention to detail and good documentation practices
  • Ability to execute protocols accurately and manage multiple tasks efficiently
  • Excellent communication and organizational skills
  • Interest in mRNA process science and eagerness to learn new techniques

    • Nice to have

  • Experience producing mRNA through IVT and downstream purification
  • Familiarity with plasmid and mRNA analytics such as HPLC, UV-Vis, and TapeStation/CGE
  • Experience with plasmid DNA preparation and linearization
  • Exposure to column-based purification and tangential flow filtration (TFF)
  • Familiarity with automation liquid handling-based methods for mRNA purification, including experience operating such as Hamiltons and Tecans

    • Benefits

    NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site

    • Salary Range: $75,000 - $100,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers

    *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

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