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Biotechnology, Epigenetic Reprogramming

Group Lead, Immunology

South San FranciscoOnsiteFull TimeLead$180,000–$240,000 /yrPosted 17 days ago

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Required skills

  • cell biology
  • immunology
  • therapeutics development
  • discovery
  • infectious disease
  • inflammatory disease
  • T cell biology
  • lymphocyte biology
  • functional assays
  • pre-clinical models

Nice to have

  • experimental methods
  • pooled screening
  • functional genomics methods
  • molecular biology foundations
  • transgenic constructs
  • iterative product development cycles

Role summary

NewLimit, a biotechnology company focused on extending human healthspan through epigenetic reprogramming, seeks an experienced Immunologist with leadership experience to lead their Immunology team. This role involves developing reprogramming medicines for age-related inflammatory and infectious diseases, with a focus on T cell and regulatory T cell biology. Responsibilities include leading a team, developing functional assays and pre-clinical models, evaluating therapeutic payloads, and collaborating with cross-functional teams. The ideal candidate will have a Ph.D. in a related field, experience in therapeutics development, and deep knowledge of immunology. Preferred qualifications include experience with T cell biology, in vivo delivery, functional genomics, and product development cycles.

About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

NewLimit is seeking an immunologist with leadership experience in therapeutics to lead our Immunology team. Our Immunology program is developing reprogramming medicines to restore youthful function in aged T cells for the treatment of inflammatory & infectious diseases with a strong emphasis on T cell and regulatory T cell (Treg) biology.

What you'll do

As the leader of Immunology team, you will:

  • Lead a team of Scientists and Research Associates to develop reprogramming therapies
  • Develop functional assays and pre-clinical models for inflammatory and infectious disease indications
  • Evaluate reprogramming payloads using functional assays & pre-clinical models to validate payloads, select leads, and progress pre-clinical candidates
  • Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test reprogramming interventions
  • Contribute to NewLimit’s product development decisions, company-wide goals, and technology platform. You will be a key part of building the company in addition to your team.
  • Contribute to day-to-day execution alongside your team. Everyone Executes at NewLimit.

    • Requirements

  • Ph.D. in cell biology, immunology, or a related field or comparable industry experience
  • Experience leading a team and managing direct reports
  • Experience with therapeutics development, ideally leading a portion of a discovery or development process in an immunology, infectious disease, or inflammatory disease setting
  • Deep knowledge of immunology & lymphocyte biology

    • Nice to have

  • Direct experience with T cell biology, including relevant functional assays, pre-clinical models, and experimental methods
  • Experience with in vivo nucleic acid delivery technologies
  • Experience with pooled screening and related functional genomics methods
  • Strong molecular biology foundations and experience designing transgenic constructs
  • Experience with iterative product development cycles (e.g. design-build-test-learn)
  • Knowledge of aging biology, computational biology, and machine learning

    • Benefits

    NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site

    • Salary Range: $180,000 to $240,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

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