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Biotechnology, Epigenetic Reprogramming

Scientist, Metabolism

South San FranciscoOnsiteFull Time$130,000–$165,000 /yrPosted 1 month ago

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Required skills

  • cell biology
  • molecular biology
  • biochemistry
  • primary liver cell isolation
  • functional characterization
  • transgenic manipulation
  • viral vectors
  • nucleic acid delivery
  • experimental record-keeping
  • project management

Nice to have

  • drug development program
  • pre-clinical development
  • clinical development
  • single cell genomics
  • pooled screening
  • CRISPR fitness screens

Role summary

NewLimit, a biotechnology company focused on extending human healthspan, seeks a Scientist specializing in Metabolism. This role involves developing and testing epigenetic reprogramming medicines for aged hepatocytes in metabolic disease contexts. Responsibilities include designing and executing in vivo experiments, developing functional assays, analyzing data to drive decisions, and collaborating with cross-functional teams. The ideal candidate has a Ph.D. in a relevant life science field, experience with liver biology, primary cell culture, mouse models, and transgenic manipulation. Preferred qualifications include drug development experience, single cell genomics, pooled screening, and machine learning.

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Description

NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.

As a Scientist on our team, you will:

  • Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
  • Develop assays to preclinical models of liver disease to measure hepatocyte function
  • Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates
  • Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
  • Analyze and interpret experimental data to drive pre-clinical decision making

    • Requirements

  • Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
  • Experience with primary liver cell isolation and functional characterization
  • Experience working with mouse models of liver dysfunction
  • Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
  • Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project

    • Nice to have

  • History of contributing to a drug development program at the pre-clinical or clinical development stage
  • Experience leading the design and execution of pre-clinical studies in mouse models
  • Experience with single cell genomics methods
  • Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

    • Benefits

    NewLimit offers generous benefits to ensure our team can focus on our mission:

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site

    • Salary Range: $130,000 to $165,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers

    *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future

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