Biotechnology, Artificial Intelligence, Drug Discovery, Machine Learning

Research Associate / Senior Research Associate, Genomic Core

South San Francisco, CAOnsiteFull TimeSenior$90,000–$115,000 /yrPosted 1 month agoVisa sponsorship available

Is this role right for you?

Upload your resume and get a skill-by-skill breakdown — see exactly where you match, where you're close, and what to highlight. Not a mystery percentage.

Get a tailored resume highlighting what this role needs.

Required skills

Genomic Core
next-generation sequencing
Illumina-based sequencing technologies
library preparation
single-cell workflows
sequencer operation
DNA
RNA
sequencing libraries
DNA and RNA

Nice to have

10x Genomics GEM-X
10x Genomics Flex assays
high-throughput sequencing pipelines
cloud-based LIMS
Benchling
BaseSpace

Role summary

Xaira is seeking a Research Associate/Senior Research Associate for its Genomic Core team, focusing on next-generation sequencing (NGS). This role involves hands-on experience with Illumina sequencing technologies, including library preparation, single-cell workflows, and sequencer operation. Responsibilities include generating high-quality sequencing data, implementing new workflows, performing quality control, and collaborating with molecular biologists and computational scientists. The ideal candidate will have a B.S./M.S. in a related field with 2+ years of laboratory experience in NGS workflows, proficiency in Illumina library preparation, and experience with sequencer operation and troubleshooting. Familiarity with single-cell workflows and quality control methods is preferred.

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

Xaira is seeking a highly motivated and detail-oriented Research Associate / Senior Research Associate to join our Genomic Core team with a focus on next-generation sequencing (NGS). The ideal candidate will have hands-on experience with Illumina-based sequencing technologies, including library preparation, single-cell workflows, and sequencer operation. This position offers the opportunity to contribute to a wide range of projects across therapeutic areas, supporting cutting-edge genomics research and technology development.

You will work closely with molecular biologists, computational scientists, and platform teams to generate high-quality sequencing data, implement new workflows, and ensure best practices in data generation and quality control.

Key Responsibilities

Prepare high-quality sequencing libraries for Illumina platforms using a range of methods (e.g., TruSeq, Nextera, Amplicon, etc.).

Operate and maintain Illumina sequencers (e.g., MiSeq, NextSeq, NovaSeq), including run setup, monitoring, troubleshooting, and basic maintenance.

Support and execute single-cell workflows, including 10x Genomics GEM-X and 10x Flex assays.

Perform QC of input material and libraries (e.g., Bioanalyzer, TapeStation, Qubit, qPCR) and assess data quality post-sequencing.

Collaborate with internal teams to support project-specific NGS needs.

Troubleshoot experimental issues independently and suggest improvements to protocols and workflows.

Develop and optimize NGS protocols and contribute to the scaling of automated or high-throughput sequencing pipelines.

Contribute to the development of scalable, high-throughput cloning and viral production pipelines.

Maintain detailed electronic lab notebook (ELN) records and ensure rigorous documentation for reproducibility and compliance.

Participate in group meetings and communicate experimental progress, challenges, and insights to broader teams.

Running analysis pipelines (e.g., bcl2fastq, CellRanger, etc).

Qualifications

B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field with 2+ years of laboratory experience, including direct experience in NGS workflows.

Proficient in Illumina sequencing library preparation methods for DNA and RNA, with a strong understanding of underlying biochemistry and assay design.

Hands-on experience with Illumina sequencer operation and troubleshooting.

Familiarity with single-cell workflows (e.g., 10x Genomics GEM-X) and/or 10x Genomics Flex assays is strongly preferred.

Experience with quality control methods for nucleic acids and libraries (e.g., fragment analysis, fluorometric quantification, library quantification).

Strong organizational skills and meticulous attention to detail in both benchwork and data documentation.

Familiarity in library cloning techniques such as vector design, PCR, assembly methods (e.g. Gibson, Golden Gate), and bacterial transformation is a plus.

Comfortable working in a fast-paced, collaborative environment, supporting multiple projects and stakeholders.

Knowledge of high-throughput or automated NGS library prep platforms is a plus.

Familiarity with cloud-based LIMS or data tracking systems (e.g., Benchling, BaseSpace) is a plus.

Basic knowledge of NGS data analysis (e.g., demultiplexing, QC metrics interpretation, familiarity with sequencing file formats) is a plus.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $90,000 - $115,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

Ready to apply?

You'll be redirected to Xaira Therapeutics's application page.